![]() Nikghalb LA, et all, 2012, Solid Dispersion: Methods and Polymers to Increase the Solubility of Poorly Soluble Drugs, Journal of Applied Pharmaceutical Science,2(10)170-175ĭitjen POM, 1979, Farmakope Indonesia Edisi 3. Liu C, Desai KG, 2005, Characteristics of Rofecoxib-Polyethylene Glycol 4000 Solid Dispersions and Tablets Based on Solid Dispersions, Pharmaceutical Development and Technology, 10:467–477 Patel BB, Patel JK, Chakraborty S, et all, 2015, Revealing Facts Behind Spray Dried Solid Dispersion Technology Used for Solubility Enhancement, Saudi Pharmaceutical Journal, 232: 352-365ĭitjen POM, 2014, Farmakope Indonesia Edisi 5.Departemen Kesehatan Republik Indonesia, Jakarta Liu J, Cao F, Zhang Can, et all, 2013, Use of Polymer Combinations in the Preparation of Solid Dispersions of a Thermally Unstable Drug by Hot-melt Extrusion, Acta Pharmaceutica Sinica B,3(4) 263-272 Beside that, the drug content test shows that the content of paracetamol in the dosage form doesn’t meet the quality requirement as established in the Indonesian Pharmacopeia. Dissolution test profile observation shows that paracetamol and PEG 4000 solid dispersion formulas have lower dissolution rate compared to pure paracetamol. Lastly, dissolution test is performed to find the increase in dissolution rate compared to pure paracetamol powder. After characterization, the amount of paracetamol in the formulationwill be measured. After the solid dispersion formed, this formula is characterized using FTIR to determine the interactions between paracetamol and PEG 4000 as a sign of formed solid dispersion. To find the effect of the amount of PEG 4000 for the solubility enhancement, two formulas of solid dispersion are made with the ratio of 1:0.5 and 1:1. Paracetamol is dispersed in PEG 4000 as hydrophilic carrier with melting method. Enhancement of solubility can be achieved by formulation of solid dispersion. This property will affect its bioavailability. Abstract - Paracetamol is one of drugs which has low solubility property in aqueous medium. ![]()
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